弗素가 發育中인 白鼠硬組織의 無機質代謝 및 弗素沈着度에 미치는 影響에 關한 硏究
THE EFFECT OF SYSTEMICALLY ADMINISTERED FLUORIDE DURING TOOTH DEVELOPMENT ON THE CONTENTS OF TRACE ELEMENTS IN HARD TISSUES
정동균,
소속 상세정보
정동균 ( ) - 서울대학교 치과대학 치과약리학교실
KMID : 0362619890100040213
Abstract
The effect of systemically admin istered flaoride during tooth calcification ,-n the cocontration of several trace el?meats to hard tissues of rats
The weanling rats, which molars almost complete it´s calcification, have been used most often as the experimental animals for anticariogenic agents. On the other hand, fluoride has been administered from the beginning of tooth calcification in clinical experiments.
In order to observe the effect of systemically administered fluoride during tooth development on the contents of several trace elements and retention rate of fluoride in the hard tissues, 2mg, 10mg, and 20mg/kg of NaF were injected intraperitoneally for various duration till 35th day after birth.
Half of above experimental animals were sacrificed and remaining half of those were saved for the retention experiment during 36th to 135th day after birth.
The results were as follow:
1) The fluoride uptake by enamel and dentin was
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determined by 1he state of the tooth Calcification at the time of fluoride administration.
2) The Alg contents of enamel and dentin were increased in fluoride administered groups, The carbonate contents of enamel and dentin were decreased in 2mg of NaF administered groups but increased in 20mg of NaF administered groups. On the other hand, Ca/P ratio had the reverse situation to the carbonate contents.
3) The metaphyses showed the highest contents of F. among the bones observed
4) The bones of 20mg of NaF administered groups were saturated with fluoride earlier than those of 2mg groups.
5) The retention rate of fluoride in bones was as follow. Metaphyses: 5o Epiphyses and Diaphyses: 20%-,-30%
6) Mg contents in bones were increased in 2mg group but decreased in 20mg groups and the aged groups.
7) Zn contents of the bones were decreased in all the fluoride administered groups.
8) Twenty mg/kg of NaF administered groups for 15th to 35th day and for 5th to 35th day after birth showed the mortality of 61Y. and 6Z%.
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